Endothelial function and insulin resistance

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Endothelial Function Varies According to Insulin Resistance Disease Type Short Title: Insulin Resistance and Vascular Function

Objective: We examined the relationship between insulin resistance and vascular function in three insulin resistant states (type 2 diabetes mellitus, non-HIV lipodystrophic diabetes, and non-diabetic polycystic ovary syndrome (PCOS)) and in healthy controls. Research Design and Methods: The population included 12 women with type 2 diabetes, 6 with lipodystrophic diabetes, 10 with polycystic ova...

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Endothelial function varies according to insulin resistance disease type.

OBJECTIVE We examined the relationship between insulin resistance and vascular function in three insulin-resistant states (type 2 diabetes, non-HIV lipodystrophic diabetes, and nondiabetic polycystic ovary syndrome [PCOS]) and in healthy control subjects. RESEARCH DESIGN AND METHODS The population included 12 women with type 2 diabetes, 6 with lipodystrophic diabetes, 10 with PCOS, and 19 hea...

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Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

Most research on insulin resistance has focused on impaired signaling at the level of target tissues like skeletal muscle. Insulin delivery is also important and includes recruitment and perfusion of capillaries bearing insulin, but also the transit of insulin across the capillary endothelium. The mechanisms of this second stage (insulin transcytosis) and whether it contributes to insulin resis...

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Insulin resistance: vascular function and exercise

Insulin resistance associated with metabolic syndrome and Type 2 diabetes mellitus is an epidemic metabolic disorder, which increases the risk of cardiovascular complications. Impaired vascular endothelial function is an early marker for atherosclerosis, which causes cardiovascular complications. Both experimental and clinical studies indicate that endothelial dysfunction in vasculatures occurs...

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Vascular and Platelet Function in Insulin Resistance

This thesis is based on the following original publications, which are referred to in the text by their Roman numerals.

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ژورنال

عنوان ژورنال: Folia Pharmacologica Japonica

سال: 2008

ISSN: 0015-5691,1347-8397

DOI: 10.1254/fpj.131.85